Posts

Unmengen an Literatur zu Isoflavonen

Wenn man sich ein bisschen Zeit nimmt und im Netz recherchiert, findet man Unmengen an Literatur zu Isoflavonen, Adiol, dem Estrogen-Rezeptor β und anderen Dingen, über die mich Uwe unterrichtet hat. Die meisten Quellen sind durchaus positiv, also in Uwes Sinne. Es gibt auch kritische Stimmen, aber da scheinen kommerzielle Interessen vorzuliegen - objektiv scheinen sie mir nicht zu sein.

Insgesamt gesehen, zeigt sich, dass es bereits viele Produkte gibt, die auf Isoflavonen basieren. Uwe war jedoch der Meinung, dass diese Produkte im Allgemeinen zu niedrig dosiert seien und sich die eigentliche Wirkung in Bezug auf schwere seelische Störungen, Infektionskrankheiten und Krebs erst bei einer weit höheren Dosis entfalte.

Mich persönlich interessiert an der ganzen Angelegenheit nur das Wissenschaftliche. Kommerzielle Ambitionen habe ich nicht. Ich lebe von meiner Arbeit als "Hirnwerker" in der Software-Industrie.

http://meridianvalleylab.com/testosteron-metabolite-3b-adiol
Very i…

Ein Problem aus der Kombinatorik

Da ich in diesem Blog so wenig über Mathematik schreibe, habe ich mir gedacht, ich poste hier meine Lösung zu einem Problem aus der Kombinatorik, das mir am 1. Februar 2018 gestellt worden ist. Das Problem lautete: 20 people work in an office, and the boss is about to select six people at random to form a committee. What are the chances that Albert and Bilbert both end up on that committee? Die Lösung:
Zu Ihrer Frage: Ich werde sie gleich für den allgemeinen Fall beantworten. Für Ihren speziellen Fall gilt:  n := 20
k := 6
p := 2  Es gibt insgesamt n choose k Möglichkeiten, wie man aus einer Gesamtmenge von n Personen Gruppen mit k Mitgliedern bilden kann (siehe Wikipedia, Stichwort "Binomialkoeffizient"). Uns interessiert, wie viele von diesen Möglichkeiten die p angegebenen Personen beinhalten. Dazu rechnen wir aus, wie viele Möglichkeiten mindestens eine dieser p Personen nicht beinhalten, und subtrahieren diesen Wert von n. Wie viele Möglichkeiten beinhalten genau eine …

Uwe was right!

It is time for a review. I am collecting scientific papers on a regular basis and since 2016, when Uwe Rohr died, there have been several publications related to his hypotheses. Most of them confirm what he stated, so it is safe to say: "Uwe was right!"

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
http://science.sciencemag.org/content/359/6376/693
Gandal et al. performed meta-analyses of transcriptomic studies covering five major psychiatric disorders and compared cases and controls to identify coexpressed gene modules. From this, they found that some psychiatric disorders share global gene expression patterns. This is exactly what Uwe said: Severe mental diseases, no matter whether it is schizophrenia, bipolar disorder or other diseases such as autism, are induced by stress. Stress affects the steroidal hormone cascade, and this effectively alters gene expression.

Meditation and vacation effects have an impact on disease-associ…

My Reading List 2017

In 2017, I have bought a lot of books. This is only an excerpt from the complete list:

1. Turings Kathedrale (George Dyson, 2012). Original title: Turing's Cathedral. A book about computers, especially about the early days when people such as Alan Turing and John Von Neumann were still alive. Status: not finished reading yet. I have started reading it again and again several times because I wanted to memorize more details. I have not got close to even 50% of the text yet.

2. Outliers (Malcolm Gladwell, 2008). A very good book. Status: not finished reading yet. I have read only the first couple of chapters. I wrote about them in my blog a couple of weeks ago. I have not arrived closer to the end of the text yet.

3. Der soziale Schwan (Florian Willet, 2013). A German book that tries to make a synthesis of Darwinism, Economics, Social Sciences, etc. Very original ideas. Too bad the style is quite amateurish. Status: not finished reading yet. So far, I have read about 20% of the text.

Celebrating 20 years of demoscene activity

I just remembered it was about the end of 1997, when I was 14 years old, that I started hanging out on demoscene IRC channels. So it is my personal 20 year anniversary now. I have definitely been involved in the demoscene. It is not justified if somebody says I have no demoscene connections. In April 1998, I won an x86 Assembler size coding contest organized by a demoscene magazine. My own diskmag has focused on the demoscene since issue 11, from June 1998. Since 2008, I have participated in several demoscene competitions with my 256b intros and gamedev projects. So I have actually made more than only the diskmag. I think this is enough for me to be called a demoscener. Of course, more is yet to come.

I am going to participate in the Demobit 2018 competitions with a photo and a 256 byte intro. If you happen to live close enough to Bratislava and have free time in the beginning of February, I highly recommend that you come to the party! I have already been there in 2017 and enjoyed it …

Can the State of the Universe be Stored in a Computer?

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This article is a follow-up to my essay "The Universe as Automaton", which I published in WIN ONE, issue 11, from 2013. There, I developed the idea that the state of the universe might be modeled as a three-dimensional matrix and that the entire history of the universe could be represented as a state machine (automaton). In this article I also wrote: "It is not possible to have something that is as large as the entire universe represented by a computer - except, maybe, if it has enough redundancy that a suitable data compression algorithm could be applied." This is what I would like to investigate further now. Can a state of the universe be stored on a computer harddrive? What obstacles are connected with this endeavour?

As a computer is part of the universe, it is obvious that the state of the universe can be stored on its harddrive only if we use some sort of encoding that acts as a data compressor. After all, the file that stores the state of the universe must …

Forschungsprojekt Hormone - Psychische Erkrankungen

Meine Gruppe hat im vergangenen Jahr diese Publikation herausgebracht, über den Zusammenhang zwischen Veränderungen in der steroidalen Hormonkaskade und seelischen Erkrankungen. Jetzt möchten wir weiter daran arbeiten und suchen jemanden, der eine Anstellung an einer österreichischen oder deutschen Universität hat. Es bestünde die Möglichkeit, ein Forschungsstipendium für die Zusammenarbeit mit einem Team in Indien zu bekommen.

Bitte meldet euch rasch, denn es ist nur mehr bis 30. November 2017 Zeit, das Projekt einzureichen!
Horm Mol Biol Clin Investig. 2016 Mar;25(3):157-70. doi: 10.1515/hmbci-2015-0038.
Model approach for stress induced steroidal hormone cascade changes in severe mental diseases.  Volko CD, Regidor PA, Rohr UD.  Abstract  INTRODUCTION:  Stress was described by Cushing and Selye as an adaptation to a foreign stressor by the anterior pituitary increasing ACTH, which stimulates the release of glucocorticoid and mineralocorticoid hormones. The question is raised whethe…